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Empatica

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Biomarker Development

Building the future of medicine, one data point at a time

Detect and monitor health conditions and changes in physiology using our range of custom biomarkers, all collected via Empatica’s medical-grade wearable sensors.

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Pioneering new approaches in clinical trials and healthcare

Empatica’s biomarkers and wearables are already being used in hundreds of studies to continuously collect health information from patients and study participants, and indicate changes in their health status. This information is enabling clinicians, patients and researchers to gain an unprecedented understanding of human health, provide better care, and advance research behind treatments.

Imagine a world where patients don’t have to do the hard work

Remote measurements

Support continuous measurements outside the physical confines of the clinical environment

Less self-reporting

Biomarkers collected using advanced sensors can provide additional accuracy and objective data without burdening the patient with additional self-reports

Complete patient view

Receive an immediate, complete view of every patient’s disease progression and response to treatments

Enhanced care

Custom biomarkers can enable a deeper understanding and improved care for dozens of chronic conditions

We develop accurate physiological and behavioral biomarkers to improve healthcare diagnostics via continuous, passive and unobtrusive health monitoring that fits in everyday life

Vital signs and physiology

Equipped with a custom PPG, EDA sensors, gyroscopes, accelerometers and a peripheral thermometer, our wrist-worn devices have been designed to accurately and objectively observe physiological biomarkers 24 hours a day:

  • iconHeart Rate
  • iconVentral EDA
  • iconHRV
  • iconPeripheral temperature
  • iconRespiration
  • iconOxygen saturation

Our custom biomarkers are built in partnership with some of the world’s top institutions, and are validated in a clinical setting

NEC
Harvard University
HHS
Duke University
MIT
Convulsive seizures
Convulsive seizures

Convulsive seizures

Uses Electrodermal Activity and motion to automatically detect Generalized Tonic Clonic Seizures (GTCS) and provides insight into autonomic arousal following each seizure event, which has been found to correlate with Post-ictal Generalized EEG Suppression (PGES), an important biomarker for SUDEP.

(Ryvlin et al., 2013)

Activity/motion and EDA changes when a seizure occurs.

Actigraphy-based rest detection
Actigraphy-based rest detection

Actigraphy-based rest detection

Provides objective measures of rest quality, such as efficiency, fragmentation and movements, within the onset and offset of the identified rest period. Detects the boundaries of periods of rest based on the quantity of movement extracted from the accelerometer sensor.

Fragmentation while a person is resting, quantity of movement extracted from the accelerometer.

Sleep staging
Sleep staging

Sleep staging

Provides insight into the autonomic activity and brain dynamics during sleep through non-invasive monitoring of physiological signals overnight, and provides an overview on sleep architecture composed by light sleep (NREM 1/2), deep sleep (NREM 3), REM and wake stages.

Brain activity and movement during sleep. An overview of sleep stages.

Validation in collaboration with: Brigham and Women's Hospital Boston (2015- ongoing) Outpatient study 50+ older adults (E4+ PSG).

Boston Children's Hospital (Ongoing) Inpatient study 20+ children (E4 + PSG).

Activity
Activity

Activity

Detects and analyzes movements to determine physical activity intensity and compute distances covered during daily movements. Automatically recognizes number of steps and distinguishes between low intensity and high intensity activity, such as walking, running or other sports.

Analysis of movement (intensity, duration) while doing physical activity (sports, running, walking, etc).

Stress
Stress

Stress

Detects autonomic arousal in response to external stimuli and provides insight about the sympathetic nervous system by monitoring EDA and temperature changes/trends/values. Used in collaboration with NEC on a study involving 300 subjects in a large-scale effort to measure and combat stress in the workplace.

Autonomic arousal and temperature responses to external stimuli.

Depression
Depression

Depression

Provides insight into physiological signals associated with activity, rest, and emotional responses against Hamilton Depression Rating Scale Score (HDRS) changes. Detects both short-term and long-term patterns that enable identifying triggers and provide accurate forecasts for depression. Original research conducted by Empatica’s Chief Scientist Rosalind Picard at MIT with Empatica technology.

Accurate monitoring of changes in gold standard depression scores (HDRS) over a typical 8-week treatment period.

Predicted vs. Actual HDRS vales: Pearson correlation 0.834, p< 0.0001

Suicide
Suicide

Suicide

Used in detecting digital phenotypes related to suicidal thoughts, measuring skin conductance levels to assess changes in physiological distress.

Study conducted by Harvard University Clinical Psychologist Dr. Matthew K. Nock involving hundreds of individuals wearing Embrace2.

Influenza forecasting
Influenza forecasting

Influenza forecasting

Monitors activation of the autonomic nervous system together with behavioral patterns to identify pathogen exposures prior to the manifestation of any symptoms. Created in partnership with DRIVe and currently under validation with the collaboration of Duke University and Columbia University.

Integrating with the longitudinal Prometheus project.

Our autonomic measures are relevant to a range of medical conditions that affect the lives of billions

  • Addiction
  • Affect dysregulation
  • Alcoholism
  • Alzheimer's disease
  • Anesthesia
  • Anxiety disorder
  • Attention deficit and hyperactivity disorder
  • Autism disorders
  • Depression
  • Diabetes
  • Dialysis
  • Dysthymia
  • Endocrine disorders
  • Epilepsy
  • Hot flashes
  • Hypertension
  • Post-traumatic stress disorder
  • Quadriplegia
  • Sensory processing and modulation
  • Schizophrenia
  • Sexual dysfunction
  • Sleep disorders
  • Oppositional defiant disorder
  • Stroke
  • Bipolar disorder
  • Cystic fibrosis
  • Dementia
  • Hypoglicemia
  • Pain management
  • Parkinson's disease
  • Temporary paralysis
  • Thyroid disfunction

Interested in hearing more about our digital biomarkers, or collaborating on new biomarker development or customization?

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Embrace is currently available only in English. Embrace is an investigational device in the USA and a medical device in the EU. If you do not see your country listed, please visit the International site.
Please note that Embrace Alert System is not available in the following countries .